Place saucepan on medium heat.
Add ketchup, brown sugar, and honey.
Stir until sugar dissolves fully.
Add vinegar, Worcestershire, and hot sauce.
Mix with a whisk until smooth.
Sprinkle paprika, garlic, and onion powder.
Stir well to blend spices evenly.
Add cayenne, salt, and black pepper.
Reduce heat to low.
Simmer sauce for 10 minutes.
Stir occasionally to avoid sticking.
Remove from heat and cool slightly.
Store in a jar or serve immediately.